Can a 5000-year-old healing system be powered by 21st-century science? This pivotal review highlights the transformative synergy between Ayurveda and nanotechnology, proving that traditional preparations like Bhasmas inherently operate at the nanoscale. This comprehensive review details how integrating nanotechnology fundamentally enhances the therapeutic efficacy of Ayurvedic Dravyas by dramatically improving their solubility, permeability, and absorption.